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False-positive breast screens might uncover risk

CHAPEL HILL, N.C. – Women who have had false-positive formula on mammograms might face a larger risk of destiny breast cancer, according to a new investigate led by a UNC-Chapel Hill researcher.

The commentary were published final week in Cancer Epidemiology, Biomarkers Prevention, that is a biography of a American Association of Cancer Research.

The investigate analyzed 2.2 million mammograms from 1.3 million U.S. women who ranged in age from 40 to 74.

It found that women with a false-positive outcome who were referred for serve imaging had a 39 percent larger possibility of building breast cancer within 10 years, compared with women who had a loyal disastrous mammogram. For women who were told to get biopsies after false-positive readings, a increasing risk was 76 percent during a successive 10-year period.

In a United States, 67 percent of women over 40 bear screening mammography each year or two. If a radiologist spots questionable tissue, a studious will be referred for serve imaging or a biopsy, depending on a turn of concern.

False-positive readings on mammograms are sincerely common, pronounced a study’s lead researcher, Louise Henderson, partner highbrow of radiology during a UNC School of Medicine and researcher during a UNC Lineberger Comprehensive Cancer Center.

Ten percent to 16 percent of mammograms beget a false-positive result. If screened each year or two, about half of women can pattern a false-positive outcome opposite 10 mammograms, Henderson said.

“For women, we commend that any boost in risk is worrisome for them, though we don’t wish women to be sincerely concerned, since a comprehensive risk is indeed sincerely small,” Henderson said.

She pronounced women should speak to their physicians if they have a false-positive outcome and also cruise other risk factors they might have.

There are many risk factors for breast cancer and some, such as genetic mutations, are clever predictors. Other risks embody a woman’s age and a firmness of her breasts.

While women with some-more unenlightened breasts face a aloft risk of breast cancer in general, firmness did not impact a attribute between false-positive mammograms and successive cancer diagnoses for many women. Breast firmness can impact a readability of mammograms.

Henderson pronounced a study’s commentary advise that radiologists who review mammograms might notice abnormalities that, while not cancerous, might be markers for destiny cancer. The investigate did not embody an research of a locations of tumors compared to initial problems speckled on mammograms.

Henderson and her colleagues analyzed information from a Breast Cancer Surveillance Consortium from 1994 to 2009. The information came from 7 registries in a United States, including a Carolina Mammography Registry, that draws information from mammography centers opposite North Carolina.

The researchers tracked women in a investigate for 10 years. During a period, 48,735 women were diagnosed with breast cancer.

Understanding a information around mammograms might in a destiny assistance scientists pattern optimal impediment and screening techniques for individuals.

“Our ultimate idea is to hopefully take information like this and use it in things like risk-prediction models to assistance women get a clarity of ‘What does it unequivocally meant for me?’” Henderson said.

The investigate was saved by a National Cancer Institute. Other researchers participating were from a University of Pennsylvania, a University of Vermont, a Group Health Research Institute in Seattle and a University of California, San Francisco.

Article source: http://www.abqjournal.com/694654/living/falsepositive-breast-screens-may-show-risk.html

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