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New blood thinner ‘antidote’ to assistance doctors pierce past warfarin


NEW YORK A new category of blood thinners that competes with widely used warfarin should get a boost subsequent year when an “antidote” that can retreat a medications’ effects in an puncture is approaching to enter a market, according to tip U.S. heart doctors and investors.

Xarelto, from Bayer AG and Johnson Johnson, and Eliquis, sole by Bristol-Myers Squibb and Pfizer, were authorized as safer and some-more available alternatives for preventing blood clots and strokes than warfarin.

But there was one hitch: there was no approach to fast revive normal clotting for patients in need of puncture medicine or to stop a vital draining episode, heading many doctors to reason off on prescribing a drugs.

“It might be uncommon, though they’re noted when they happen,” Dr. Charles Pollack, an puncture medicine during Thomas Jefferson University Hospital in Philadelphia, pronounced of vital draining events.

“We didn’t have a specific annulment plan for these drugs, and we consider that left people feeling a bit insecure,” combined Pollack, who has finished clinical work on a recently authorized remedy to Boehringer Ingelheim’s opposition blood clot preventer Pradaxa.

That is about to change.

Small drugmaker Portola Pharmaceuticals this month practical for U.S. capitulation of a drug called andexanet alfa that fast reverses a outcome of Xarelto and Eliquis. It is approaching to enter a marketplace in 2016.

“It will make a large difference,” pronounced Dr. Mariell Jessup, a cardiologist during a University of Pennsylvania Medical Center. “I have many physicians, quite surgeons, who hatred these drugs. They’re fearful of them since they’ve had to understanding with a consequences of somebody entrance in with trauma,” while regulating a new blood thinners.

The new drugs means fewer vital draining episodes than warfarin and do not need dietary restrictions or consistent monitoring as with a decades-old medicine. But vital draining stays a many worrisome risk of all anti-coagulant therapy as it can be deadly or means debilitating, long-term problems.

Bristol-Myers reported $466 million in tellurian third-quarter sales of Eliquis, that won U.S. capitulation during a finish of 2012, about 18 months after Xarelto. JJ posted U.S. Xarelto sales of $461 million in a quarter, while Bayer reported about $509 million in general sales.

There is still a lot of room to grow as warfarin, also prescribed underneath a code name Coumadin, commands some 60 percent of a blood thinner market. Morningstar expects annual sales for Xarelto and Eliquis could strech $8 billion for each.

PAYERS SEE VALUE

The treatments are about 70 times some-more costly than pennies-a-day warfarin, according to Express Scripts Holding Co, a largest U.S. pharmacy advantages manager. But given a higher reserve and convenience, Express Scripts pronounced in a matter that “the altogether value is expected justified.”

Health insurer Aetna Inc expects capitulation of a Portola drug to gradually boost use of Xarelto and Eliquis, pronounced Edmund Pezalla, Aetna’s inhabitant medical executive for curative process and strategy.

Xarelto and Eliquis are authorized to provide patients with a form of strange heartbeat called atrial fibrillation that significantly increases cadence risk, as good as to forestall blood clots following hip or knee replacement, and to provide low capillary thrombosis and pulmonary embolism.

Paul Burton, clamp boss of medical affairs for Johnson Johnson’s Janssen unit, stressed Xarelto’s reserve though pronounced accessibility of Portola’s drug would raise alloy comfort levels.

The Xarelto partnership is seeking additional authorized uses, with trials underway in patients with strident coronary syndrome, and for rebate of vital inauspicious cardiovascular events in patients with heart disaster or marginal artery disease.

Bristol and Pfizer have a direct-to-consumer radio ad debate to boost Eliquis awareness.

“We trust that a annulment representative could be an critical care for physicians when initiating Eliquis and switching suitable patients from warfarin to Eliquis,” Bristol and Pfizer pronounced in a corner statement.

Portola’s annulment drug “will positively assistance sales. Anybody who was watchful on a sidelines will not be fence-sitting anymore,” pronounced Les Funtleyder, medical portfolio manager for E Squared Capital Management, that binds Pfizer shares.

The drug would turn Portola’s initial product on a market.

Cowen and Co foresee $355 million in sales by 2020 for a antidote. Portola is also building a drug to opposition Xarelto and Eliquis.

Duke University’s Dr. Jerrold Levy likely that all hospitals will batch a Portola antidote.

“It increases a reserve margin,” Levy said.

(Reporting by Bill Berkrot; Editing by Michele Gershberg and Will Dunham)

Article source: http://www.reuters.com/article/us-pharmaceuticals-bloodthinners-idUSKBN0U617320151223

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