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Study Explores Expanded Use For Edwards’ And Medtronic’s New Heart Valves

In a final few years transcatheter aortic valve replacements from Edwards Lifesciences and Medtronic have entered a marketplace and now offer an choice to medicine for some patients. Now these valves are being deliberate for use in patients who have already undergone medicine yet whose bioprosthetic valves have failed.

Although surgeons and patients increasingly cite bioprosthetic valves to automatic valves, a arch obstacle to a bioprosthetic valves is that they might eventually deteriorate, that means that some-more and some-more physicians and patients will fundamentally be faced with a quandary of how best to provide degenerated valves. Although surgical reoperation is deliberate a best solution, many patients are too aged and thin for surgery. Transcatheter aortic valve implantation (TAVI) has been due for use in this situation, yet a risks and advantages have not as yet been good defined.

Now, a new investigate in JAMA provides information on 459 patients with unsuccessful bioprosthetic valves who underwent TAVI with possibly a Edwards Sapien device or a Medtronic Corevalve device.  The investigators in a VIVID (Valve-in-Valve International Data) Registry news that a genocide rate was 7.6% during one month and 16.8% during one year. A sum of 39.5% of valve failures were due to stenosis, 30.3% due to regurgitation, and 30.3% due to a multiple of a two. Survival was lowest in a stenosis organisation and in patients with tiny valves compared with patients with intermediate-size or vast valves.

Cardiologist David Hillis offering an judicious viewpoint on this paper:

Inevitably, some recipients of bioprosthetic valves knowledge prosthetic valve disaster and need some form of re-do procedure.  A repeat surgical AVR carries a estimable risk, given (1) these patients are mostly utterly elderly, and (2) any re-operation potentially can be high-risk (any time one cuts into a chest that has been cut on previously, surprises infrequently await — i.e., things is stranded to other things that creates a procession formidable and difficult).  Bioprosthetic valve disaster is not common — yet it does occur, quite with prostheses that have been in place for 10-12 years.  Having a nonsurgical choice to repeat AVR is attractive.  This registry knowledge simply concludes that behaving TAVI in these people is a reasonable alternative.  Is it improved than repeat surgical AVR?  Obviously, this paper doesn’t answer that question.

In short, we would tenure this a “feasibility study” — doing TAVR on these subjects is feasible.”


Article source: http://www.forbes.com/sites/larryhusten/2014/07/08/study-explores-expanded-use-for-edwards-and-medtronics-new-heart-valves/

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